CE-IVD and NMPA Approved | Precision Molecular Diagnostics for Solid Tumors

Genecast Focus is a clinically validated, CE-IVD and NMPA approved targeted NGS assay for solid tumor profiling. It enables accurate detection of key biomarkers across 41 driver genes and MSI status, empowering personalized oncology treatment decisions

DNA extracted from FFPE tissue is used to detect SNVs, Indels, CNVs, and MSI, while RNA is analyzed to identify gene fusions and rearrangements. The kit accurately and rapidly provides patients with mutation information relevant to targeted drugs, immunotherapy drugs . 

Guiding Treatment with Actionable Genomic Insights

• Precise matching for targeted therapy:

  Simplifies the screening process for targeted therapy and accelerates clinical decision-making. By detecting mutations, amplifications, or fusions in common driver genes (e.g., EGFR, KRAS, BRAF, ALK, ROS1), the test helps clinicians determine whether a patient is suitable for targeted treatment.

• Identification of potential beneficiaries of immunotherapy:

  Supports assessment of immunotherapy indications, particularly for patients with MSI-H or mutations in POLE/POLD1.

Multi-Dimensional Gene List Aligned with Clinical Needs

Applicable Across a Wide Range of Solid Tumors

• Targeting 41 Driver Genes and MSI to Support Personalized Treatment Decisions

• Suitable for non-small cell lung cancer, colorectal cancer, gastric cancer, gastrointestinal stromal tumors, thyroid cancer, bladder cancer, esophageal cancer, melanoma, biliary tract malignancies, and a wide range of other solid tumors.

Who Should Consider This Test?

• Patients with solid tumors requiring initial treatment decision support

  To assess eligibility for targeted therapies and potential benefit from immunotherapy based on key biomarkers such as EGFR, ALK, BRAF mutations, MSI-H, and POLE/POLD1 mutations.

• Patients seeking more comprehensive profiling through combined DNA and RNA analysis

  Suitable for identifying both gene mutations and gene fusions. Provides a more complete molecular landscape to support personalized treatment decisions

• Patients with limited or low-quality tumor tissue samples

  Small biopsy volume or archived FFPE samples collected within the past 3 years

• Patients in early-stage or locally advanced settings

  To support neoadjuvant treatment planning and post-surgical risk stratification and adjuvant therapy selection

Why Choose Genecast Focus

• Comprehensive Coverage of Actionable Genes

  Genecast Focus targets 41 key driver genes and over 900 hotspot regions across major solid tumors such as non-small cell lung cancer and colorectal cancer. It provides clinically actionable information to guide both targeted therapies and immunotherapy decisions.

• Highly Sensitive Detection with Minimal Input

  With as little as 10 ng of DNA, the assay can detect somatic mutations down to 1% allele frequency. Using just 50 ng of RNA, it reliably identifies gene fusions and rearrangements with a detection limit of 100 copies, making it suitable even for low-yield clinical samples.

• Flexible Compatibility with Challenging Samples

  Focus is optimized for formalin-fixed, paraffin-embedded (FFPE) tissue samples, including those with degraded DNA or RNA. This makes it ideal for use with archived or limited-quantity tumor specimens.

• Internationally Certified and Clinically Approved

  Genecast Focus is CE-IVD certified and approved by the NMPA in China, ensuring high standards of quality, reliability, and regulatory compliance for clinical application.

Sample Requirements

Testing Workflow & Ordering Process

TAT time：2 bussiness days*

(*) Turn-around time takes effect upon sample arrival at Genecast Singapore lab and clears sample quality checks.

1. Complete the Test Requisition Form

   The ordering physician or patient fills out the form with relevant clinical and sample information.

2. Send Samples

   Submit the required samples—such as FFPE blocks/slides/wax roll—to the Genecast laboratory.

3. Sample Receipt & Registration

   Samples are inspected upon arrival and logged into our system for processing.

4. DNA & RNA Extraction

   High-quality DNA and RNA are extracted from the submitted samples.

5. Library Preparation

   Sequencing libraries are prepared using standardized protocols to ensure accuracy and consistency.

6. Next-Generation Sequencing

   High-throughput sequencing is performed to detect relevant genomic alterations.

7. Bioinformatics Analysis

   Advanced proprietary algorithms are applied to identify clinically actionable variants.

8. Report Delivery

   The test report is generated and delivered to the designated email for clinical use.